A New Tumor Suppressor Gene, Selective for Lung Cancer
نویسندگان
چکیده
منابع مشابه
A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3.
Frequent allelic loss and homozygous deletions within chromosome 3p in human lung cancers have suggested that the 3p21.3 (370-kb) region contains a critical tumor suppressor gene(s) (TSG). With the exact identity/characteristics of such a gene(s) still unconfirmed, a lack of inactivating structural mutations in the expressed genes contained within this region may indicate that the 3p TSG(s) do ...
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BACKGROUND WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic. The aim of this study was to describe (i) putative protein interactions of WWOX (ii) the mo...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2007
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djm227